By 2050 the tallest buildings may be over 50km, again almost exclusively for space travel, and space ports will be more common. Many residents will be androids, but there will also be new biological creatures, genetically designed and lab-assembled, and some might be able to talk and interact well with people, with part of their intelligence based in the cloud.
These will start to replace conventional pets, so we might see androids taking Furbies for walks. Ground and building transport will be almost entirely pod based, and elevators might also be replaced by such pods using internals shafts and external surfaces. People will have minds linked to the net so will be able to communicate telepathically with each other and with machines.
With a lot of things happening virtually, people might sit or stand still for ages while doing things in virtual worlds instead.